热适应仓鼠的碳水化合物代谢。V. 糖异生的调控。

Carbohydrate metabolism of heat-acclimated hamsters. V. Control of gluconeogenesis.

作者信息

Chayoth R

出版信息

J Appl Physiol. 1976 Dec;41(6):871-7. doi: 10.1152/jappl.1976.41.6.871.

DOI:10.1152/jappl.1976.41.6.871

Abstract

The rate of gluconeogenesis was similar in liver of both fed heat-acclimated and control hamsters. Twenty-four hours of fasting calsed 6 times elevation in hepatic gluconeogenesis of the control animals whereas only 4 times enhancement of this pathway was found in heat-acclimated animals. Thus, significant difference existed between the two experimental groups in fasting. Triiodothyronine stimulated the rate of gluconeogenesis only in fed heat-acclimated hamsters whereas dibutyryl cyclic AMP caused elevation of this pathway in liver slices of fed control hamsters only. The results suggest that a decrease in hepatic gluconeogenesis in heat acclimation occurs only in fasted animals and it is controlled by thyroid hormones.

摘要

喂食状态下经热适应的仓鼠和对照仓鼠肝脏中的糖异生速率相似。禁食24小时会使对照动物的肝脏糖异生增加6倍，而在经热适应的动物中，该途径仅增强4倍。因此，两个实验组在禁食状态下存在显著差异。三碘甲状腺原氨酸仅在喂食状态下经热适应的仓鼠中刺激糖异生速率，而二丁酰环磷腺苷仅使喂食状态下对照仓鼠肝脏切片中的该途径升高。结果表明，热适应过程中肝脏糖异生的降低仅发生在禁食动物中，且受甲状腺激素控制。