Reddi A H, Cunningham N S
Bone Cell Biology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
J Biomech Eng. 1991 May;113(2):189-90. doi: 10.1115/1.2891233.
Implantation of demineralized bone matrix results in local bone induction. Bone induction is a sequential biological chain reaction that consists of chemotaxis and proliferation of mesenchymal cells and differentiation of bone. Osteogenin, a bone morphogenetic protein has been purified and the amino acid sequence determined. Recently a family of bone morphogenetic proteins have been cloned and expressed by recombinant DNA technology. The availability of growth and morphogenetic factors will permit the rational design of new bone. The challenge for the biomechanical engineer is to attain mechanically optimal and functionally adaptive new bone for various skeletal prostheses. We are on the threshold for fabrication of new bone based on sound architectural design principles of tissue engineering based on cellular and molecular biology of growth and differentiation factors.
脱矿骨基质的植入会导致局部骨诱导。骨诱导是一个由间充质细胞的趋化性和增殖以及骨分化组成的连续生物连锁反应。骨生成素，一种骨形态发生蛋白已被纯化并确定了氨基酸序列。最近，一个骨形态发生蛋白家族已通过重组DNA技术被克隆和表达。生长和形态发生因子的可得性将允许合理设计新骨。生物力学工程师面临的挑战是为各种骨骼假体获得机械性能最佳且功能适配的新骨。基于生长和分化因子的细胞与分子生物学的组织工程合理架构设计原则，我们正处于制造新骨的开端。
