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Structural basis for the catalytic mechanism of human phosphodiesterase 9.
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The mechanism of cyclic nucleotide hydrolysis in the phosphodiesterase catalytic site.
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Structural insight into substrate specificity of phosphodiesterase 10.
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Enzyme assays for cGMP hydrolyzing phosphodiesterases.
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Structural basis for the activity of drugs that inhibit phosphodiesterases.
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Inactivation of Non-canonical Cyclic Nucleotides: Hydrolysis and Transport.
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Structural and functional dynamics of human cone cGMP-phosphodiesterase important for photopic vision.
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Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6.
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Virtual Screening-Accelerated Discovery of a Phosphodiesterase 9 Inhibitor with Neuroprotective Effects in the Kainate Toxicity In Vitro Model.
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Identified Isosteric Replacements of Ligands' Glycosyl Domain by Data Mining.
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Enzyme Inhibitors from Gorgonians and Soft Corals.
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Inhibition of phosphodiesterase: A novel therapeutic target for the treatment of mild cognitive impairment and Alzheimer's disease.
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Combined ligand-based and structure-based design of PDE 9A inhibitors against Alzheimer's disease.
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Processing of X-ray diffraction data collected in oscillation mode.
Methods Enzymol. 1997;276:307-26. doi: 10.1016/S0076-6879(97)76066-X.
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The mechanism of cyclic nucleotide hydrolysis in the phosphodiesterase catalytic site.
J Phys Chem B. 2007 May 3;111(17):4547-52. doi: 10.1021/jp066582+. Epub 2007 Apr 11.
4
Structural insight into substrate specificity of phosphodiesterase 10.
Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5782-7. doi: 10.1073/pnas.0700279104. Epub 2007 Mar 26.
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Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.
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Refinement of macromolecular structures by the maximum-likelihood method.
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A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases.
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Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding.
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9624-9. doi: 10.1073/pnas.0401120101. Epub 2004 Jun 21.

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