Couto Suzana S, Cardiff Robert D
Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Room Z- 930, P.O. Box 270, New York, NY 10065, USA.
Endocr Pathol. 2008 Fall;19(3):139-47. doi: 10.1007/s12022-008-9042-2.
The genome has been sequenced. However, the functions of each gene remain to be elucidated through phenotypic analysis. This analysis has been called phenogenomics. That part of phenogenomics related to disease can be called pathogenomics or Genomic Pathology. The initial phases of disease analysis will use genetically modified mice. The proliferation of ambitious programs designed to use mice for phenogenomics has been met with alarm by comparative pathologists who note the lack of qualified genomic pathologists and of training programs in genomic pathology. While endocrine pathology offers a number of excellent examples of the contributions made by pathologists to the scientific literature, it also contains examples of the hazards of working with untrained, unwary personnel.
基因组已被测序。然而，每个基因的功能仍有待通过表型分析来阐明。这种分析被称为表型基因组学。表型基因组学中与疾病相关的部分可称为疾病基因组学或基因组病理学。疾病分析的初始阶段将使用基因改造小鼠。旨在将小鼠用于表型基因组学的雄心勃勃的项目不断增加，这引起了比较病理学家的警觉，他们指出缺乏合格的基因组病理学家以及基因组病理学培训项目。虽然内分泌病理学提供了许多病理学家对科学文献做出贡献的优秀范例，但它也包含了与未经培训、粗心大意的人员合作所带来危害的例子。
