Strock Paul, Mossong Joël, Hawotte Karine, Arendt Vic
Hepatogastroenterology, Service d'Hépato-Gastroentérologie, Centre Hospitalier de Luxembourg, Luxembourg-City, Luxembourg.
Dig Dis Sci. 2009 Jun;54(6):1325-30. doi: 10.1007/s10620-008-0483-8. Epub 2008 Aug 29.
We conducted a prospective study to investigate access to treatment in hepatitis C in 268 prisoners. Hepatitis C positivity had been known for 182 prisoners previously and 19 reported previous attempts to treat (10%). In comparison, during our study, 86/268 prisoners (32%) started therapy (P < 0.0001). They represented 41% of 211 prisoners with a positive viral load. In the genotype 2 or 3 group, 46 prisoners (50%) started therapy versus 40 prisoners (33%) with other genotypes (P = 0.01). This difference was due to prisoners waiting for liver biopsy. On an intention to treat basis, 45 prisoners (52%) achieved sustained virological response 6 months after the end of therapy. We conclude that a stay in prison is an effective opportunity to treat a group of hepatitis C patients which otherwise have very limited access to therapy.
我们开展了一项前瞻性研究,以调查268名囚犯的丙型肝炎治疗情况。此前已知182名囚犯丙型肝炎呈阳性,19名报告曾尝试治疗(10%)。相比之下,在我们的研究期间,268名囚犯中有86名(32%)开始治疗(P<0.0001)。他们占211名病毒载量呈阳性囚犯的41%。在基因2型或3型组中,46名囚犯(50%)开始治疗,而其他基因型的囚犯为40名(33%)(P = 0.01)。这种差异是由于囚犯等待肝活检。在意向性治疗的基础上,45名囚犯(52%)在治疗结束6个月后实现了持续病毒学应答。我们得出结论,监禁是治疗丙型肝炎患者群体的有效机会,否则这些患者获得治疗的机会非常有限。