Corruble E, Gorwood P, Falissard B
Department of Psychiatry, Bicêtre University Hospital, INSERM U 669, Paris XI University, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France.
Acta Psychiatr Scand. 2008 Nov;118(5):389-94. doi: 10.1111/j.1600-0447.2008.01239.x. Epub 2008 Aug 27.
The recognition of later late-onset (LLO) major depression (MD) is a matter of concern.
Cross-sectional study assessed MD with the MINI structured interview and the MADRS in a referred sample of 13 377 non-demented adult out-patients visiting their physicians. Among 6850 patients with a first episode of MD, 370 LLO (75 years of age and older) MD were compared with 814 late-onset (LO) (60-74 years old) MD and 5666 early-onset (EO) (18-59 years old) MD.
There are many similarities between the symptom patterns of EO, LO and LLO MDs. However, the symptom pattern of LLO MD includes more retardation/agitation, lassitude, reduced appetite and apparent sadness, and less sleep disturbances, guilt feelings, pessimism and inner tension than LO and EO MD.
The differences in symptom profiles are very modest and between-group differences may not be meaningful on an individual level.
识别迟发性重度抑郁症（LLO）是一个值得关注的问题。
采用横断面研究，通过MINI结构化访谈和蒙哥马利-阿斯伯格抑郁量表（MADRS）对13377名前来就诊的非痴呆成年门诊患者进行评估。在6850例首发重度抑郁症患者中，将370例迟发性重度抑郁症（年龄75岁及以上）与814例晚发性重度抑郁症（60 - 74岁）和5666例早发性重度抑郁症（18 - 59岁）进行比较。
早发性、晚发性和迟发性重度抑郁症的症状模式有许多相似之处。然而，与晚发性和早发性重度抑郁症相比，迟发性重度抑郁症的症状模式包括更多的迟缓/激越、疲倦、食欲减退和明显的悲伤，而睡眠障碍、内疚感、悲观情绪和内心紧张则较少。
症状特征的差异非常微小，组间差异在个体层面可能并无意义。
