Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA 92093, USA.
Acta Psychiatr Scand. 2010 Nov;122(5):414-26. doi: 10.1111/j.1600-0447.2010.01552.x.
To determine whether late-onset schizophrenia (LOS, onset after age 40) should be considered a distinct subtype of schizophrenia.
Participants included 359 normal comparison subjects (NCs) and 854 schizophrenia out-patients age >40 (110 LOS, 744 early-onset schizophrenia or EOS). Assessments included standardized measures of psychopathology, neurocognition, and functioning.
Early-onset schizophrenia and LOS groups differed from NCs on all measures of psychopathology and functioning, and most cognitive tests. Early-onset schizophrenia and LOS groups had similar education, severity of depressive, negative, and deficit symptoms, crystallized knowledge, and auditory working memory, but LOS patients included more women and married individuals, had less severe positive symptoms and general psychopathology, and better processing speed, abstraction, verbal memory, and everyday functioning, and were on lower antipsychotic doses. Most EOS-LOS differences remained significant after adjusting for age, gender, severity of negative or deficit symptoms, and duration of illness.
Late-onset schizophrenia should be considered a subtype of schizophrenia.
确定迟发性精神分裂症（LOS，发病年龄 40 岁后）是否应被视为精神分裂症的一个独特亚型。
参与者包括 359 名正常对照组（NC）和 854 名年龄>40 岁的精神分裂症门诊患者（110 例 LOS，744 例早发性精神分裂症或 EOS）。评估包括精神病理学、神经认知和功能的标准化测量。
早发性精神分裂症和 LOS 组与 NC 组在所有精神病理学和功能以及大多数认知测试方面存在差异。早发性精神分裂症和 LOS 组的教育程度、抑郁、阴性和缺陷症状、晶体知识以及听觉工作记忆相似，但 LOS 患者中女性和已婚者更多，阳性症状和一般精神病理学较轻，处理速度、抽象思维、语言记忆和日常功能更好，抗精神病药物剂量较低。调整阴性或缺陷症状严重程度和疾病持续时间后，大多数 EOS-LOS 差异仍然显著。
迟发性精神分裂症应被视为精神分裂症的一个亚型。
