Ngure R M, Karanja S M, Mungatana N K, Wamae C N, Ngotho J M, Gichuki C W
Department of Biochemistry & Molecular Biology, Egerton University, Egerton, Kenya.
J Med Primatol. 2008 Aug;37(4):210-4. doi: 10.1111/j.1600-0684.2008.00282.x.
Thirty-four wild Chlorocebus aethiops monkeys were trapped for research purposes.
During routine quarantine check-up, cerebrospinal fluid (CSF) and blood were microscopically examined for parasites. Estimations of CSF protein levels were made by the biuret method and the white cell counts by the hemocytometer.
Seven monkeys demonstrated microfilariae in blood and CSF. This was accompanied by a two- and ninefold increase in CSF total protein and white cell counts, respectively. Necropsy of one of the blood and CSF microfilariae-positive animals revealed the presence of adult worms in the brain meninges. The parasites were identified as the zoonotic filaroid nematode Meningonema peruzii.
Wild C. aethiops monkeys developed CSF changes resulting, most probably, from infection with M. peruzii. Moreover, the monkeys could be acting as an important reservoir. The study highlights the need for epidemiological and pathogenological studies of this parasite, which is of public health significance. Moreover, C. aethiops proved to be a useful primate model for the study of this zoonotic infection.
为研究目的捕获了34只野生埃塞俄比亚绿猴。
在常规检疫检查期间，对脑脊液（CSF）和血液进行显微镜检查以寻找寄生虫。采用双缩脲法测定脑脊液蛋白水平，用血细胞计数器计数白细胞。
7只猴子的血液和脑脊液中发现了微丝蚴。同时，脑脊液总蛋白和白细胞计数分别增加了两倍和九倍。对一只血液和脑脊液微丝蚴阳性的动物进行尸检，发现脑膜中有成虫。这些寄生虫被鉴定为人畜共患的丝状线虫佩鲁齐脑膜线虫。
野生埃塞俄比亚绿猴出现脑脊液变化，很可能是由佩鲁齐脑膜线虫感染引起的。此外，这些猴子可能是重要的储存宿主。该研究强调了对这种具有公共卫生意义的寄生虫进行流行病学和病理学研究的必要性。此外，埃塞俄比亚绿猴被证明是研究这种人畜共患感染的有用灵长类动物模型。
