Lewis Hannah C, Mølbak Kåre, Reese Catrin, Aarestrup Frank M, Selchau Mette, Sørum Marit, Skov Robert L
Statens Serum Institut, Copenhagen, Denmark.
Emerg Infect Dis. 2008 Sep;14(9):1383-9. doi: 10.3201/eid1409.071576.
An emerging subtype of methicillin-resistant Staphylococcus aureus (MRSA), clonal complex (CC) 398, is associated with animals, particularly pigs. We conducted a matched case-control and a case-case study comparing 21 CC398 case-patients with 2 controls randomly selected from the Danish Civil Registry and 2 case-patients infected with MRSA other than CC398. On farms of case-patients, animals were examined for MRSA. Thirteen case-patients reported pig exposure. Living or working on farms with animals was an independent risk factor for CC398 in the case-control (matched odds ratio [MOR] 35.4, 95% confidence interval [CI] 2.7-469.8) and the case-case study (MOR 14.5, 95%CI 2.7-76.7). History of hospitalization was associated with an increased risk only in the case-control study (MOR 11.4, 95% CI 1.4-94.8). A total of 23 of 50 pigs on 4 of 5 farms were positive for CC398. Our results, corroborated by microbiologic testing, demonstrate that pigs are a source of CC398 in Denmark.
耐甲氧西林金黄色葡萄球菌（MRSA）的一种新兴亚型，克隆复合体（CC）398，与动物尤其是猪有关。我们进行了一项匹配病例对照研究和一项病例病例研究，将21例CC398病例患者与从丹麦民事登记处随机选取的2名对照以及2例感染非CC398型MRSA的病例患者进行比较。在病例患者的农场中，对动物进行了MRSA检测。13例病例患者报告有猪接触史。在病例对照研究（匹配比值比[MOR] 35.4，95%置信区间[CI] 2.7 - 469.8）和病例病例研究（MOR 14.5，95%CI 2.7 - 76.7）中，在有动物的农场生活或工作是CC398感染的独立危险因素。仅在病例对照研究中，住院史与风险增加相关（MOR 11.4，95%CI 1.4 - 94.8）。5个农场中的4个农场的50头猪中共有23头CC398检测呈阳性。我们的结果经微生物检测证实，表明猪是丹麦CC398的一个来源。
