Odaci Ersan, Bas Orhan, Kaplan Suleyman
Department of Histology and Embryology, Karadeniz Technical University School of Medicine, Trabzon, Turkey.
Brain Res. 2008 Oct 31;1238:224-9. doi: 10.1016/j.brainres.2008.08.013. Epub 2008 Aug 16.
Electromagnetic fields (EMFs) inhibit the formation and differentiation of neural stem cells during embryonic development. In this study, the effects of prenatal exposure to EMF on the number of granule cells in the dentate gyrus of 4-week-old rats were investigated. This experiment used a control (Cont) group and an EMF exposed (EMF) group (three pregnant rats each group). The EMF group consisted of six offspring (n=6) of pregnant rats that were exposed to an EMF of up to 900 megahertz (MHz) for 60 min/day between the first and last days of gestation. The control group consisted of five offspring (n=5) of pregnant rats that were not treated at all. The offspring were sacrificed when they were 4 weeks old. The numbers of granule cells in the dentate gyrus were analyzed using the optical fractionator technique. The results showed that prenatal EMF exposure caused a decrease in the number of granule cells in the dentate gyrus of the rats (P<0.01). This suggests that prenatal exposure to a 900 MHz EMF affects the development of the dentate gyrus granule cells in the rat hippocampus. Cell loss might be caused by an inhibition of granule cell neurogenesis in the dentate gyrus.
电磁场（EMFs）在胚胎发育过程中会抑制神经干细胞的形成和分化。在本研究中，调查了产前暴露于电磁场对4周龄大鼠齿状回颗粒细胞数量的影响。本实验使用了一个对照组（Cont）和一个电磁场暴露组（EMF）（每组三只怀孕大鼠）。电磁场组由怀孕大鼠的六只后代（n = 6）组成，这些怀孕大鼠在妊娠的第一天至最后一天每天暴露于高达900兆赫兹（MHz）的电磁场中60分钟。对照组由五只未接受任何处理的怀孕大鼠的后代（n = 5）组成。后代在4周龄时被处死。使用光学分割技术分析齿状回中颗粒细胞的数量。结果表明，产前暴露于电磁场会导致大鼠齿状回中颗粒细胞数量减少（P < 0.01）。这表明产前暴露于900 MHz电磁场会影响大鼠海马体齿状回颗粒细胞的发育。细胞损失可能是由于齿状回中颗粒细胞神经发生受到抑制所致。
