Bas Orhan, Odaci Ersan, Kaplan Suleyman, Acer Niyazi, Ucok Kagan, Colakoglu Serdar
Department of Anatomy, Rize University School of Medicine, Rize, Turkey.
Brain Res. 2009 Apr 10;1265:178-85. doi: 10.1016/j.brainres.2009.02.011. Epub 2009 Feb 20.
The effects of electromagnetic fields (EMFs) emitted by mobile phones on humans hold special interest due to their use in close proximity to the brain. The current study investigated the number of pyramidal cells in the cornu ammonis (CA) of the 16-week-old female rat hippocampus following postnatal exposure to a 900 megahertz (MHz) EMF. In this study were three groups of 6 rats: control (Cont), sham exposed (Sham), and EMF exposed (EMF). EMF group rats were exposed to 900 MHz EMF (1 h/day for 28 days) in an exposure tube. Sham group was placed in the exposure tube but not exposed to EMF (1 h/day for 28 days). Cont group was not placed into the exposure tube nor were they exposed to EMF during the study period. In EMF group rats, the specific energy absorption rate (SAR) varied between 0.016 (whole body) and 2 W/kg (locally in the head). All of the rats were sacrificed at the end of the experiment and the number of pyramidal cells in the CA was estimated using the optical fractionator technique. Histopathological evaluations were made on sections of the CA region of the hippocampus. Results showed that postnatal EMF exposure caused a significant decrease of the pyramidal cell number in the CA of the EMF group (P<0.05). Additionally, cell loss can be seen in the CA region of EMF group even at qualitative observation. These results may encourage researchers to evaluate the chronic effects of 900 MHz EMF on teenagers' brains.
由于手机发射的电磁场（EMF）在使用时靠近大脑，因此其对人体的影响备受关注。当前研究调查了16周龄雌性大鼠出生后暴露于900兆赫兹（MHz）电磁场后，其海马体角回（CA）中锥体细胞的数量。本研究中有三组，每组6只大鼠：对照组（Cont）、假暴露组（Sham）和电磁场暴露组（EMF）。电磁场暴露组的大鼠在暴露管中暴露于900 MHz电磁场（每天1小时，共28天）。假暴露组被置于暴露管中，但未暴露于电磁场（每天1小时，共28天）。对照组在研究期间既未放入暴露管中，也未暴露于电磁场。在电磁场暴露组的大鼠中，比吸收率（SAR）在0.016（全身）至2 W/kg（头部局部）之间变化。实验结束时处死所有大鼠，并使用光学分割技术估计CA中锥体细胞的数量。对海马体CA区域的切片进行了组织病理学评估。结果显示，出生后暴露于电磁场导致电磁场暴露组CA中锥体细胞数量显著减少（P<0.05）。此外，即使在定性观察中，也可以看到电磁场暴露组CA区域的细胞损失。这些结果可能会促使研究人员评估900 MHz电磁场对青少年大脑的慢性影响。
