Murphy Pamela K, Wagner Carol L
Medical University of South Carolina, 169 Ashley Ave., P.O. Box 250347, Charleston, SC 29425, USA.
J Midwifery Womens Health. 2008 Sep-Oct;53(5):440-6. doi: 10.1016/j.jmwh.2008.04.014.
This integrative review evaluates research studies that investigated the association between vitamin D and mood disorders affecting women to determine whether further research comparing these variables is warranted. A literature search using CINAHL, PsycINFO, MEDLINE, and PubMed databases was conducted to locate peer-reviewed mood disorder research studies that measured serum 25-hydroxyvitamin D (25[OH]D) levels. Four of six studies reviewed imparted significant results, with all four showing an association between low 25(OH)D levels and higher incidences of four mood disorders: premenstrual syndrome, seasonal affective disorder, non-specified mood disorder, and major depressive disorder. This review indicates a possible biochemical mechanism occurring between vitamin D and mood disorders affecting women, warranting further studies of these variables using rigorous methodologies.
本综述评估了研究维生素D与影响女性的情绪障碍之间关联的研究，以确定是否有必要进一步开展比较这些变量的研究。利用护理学与健康领域数据库（CINAHL）、心理学文摘数据库（PsycINFO）、医学文献数据库（MEDLINE）和医学期刊数据库（PubMed）进行文献检索，以查找测量血清25-羟基维生素D（25[OH]D）水平的同行评审的情绪障碍研究。六项综述研究中有四项得出了显著结果，这四项研究均表明低25(OH)D水平与四种情绪障碍的较高发病率之间存在关联：经前综合征、季节性情感障碍、未明确的情绪障碍和重度抑郁症。本综述表明，维生素D与影响女性的情绪障碍之间可能存在生化机制，因此有必要使用严谨的方法对这些变量进行进一步研究。
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