Tartagni Massimo, Cicinelli Maria Vittoria, Tartagni Mario Valerio, Alrasheed Hala, Matteo Maria, Baldini Domenico, De Salvia Maria, Loverro Giuseppe, Montagnani Monica
Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari "Aldo Moro", Bari, Italy.
Centro di Fecondazione Medicalmente Assistita MoMò Fertilife, Bisceglie, Italy.
J Pediatr Adolesc Gynecol. 2016 Aug;29(4):357-61. doi: 10.1016/j.jpag.2015.12.006. Epub 2015 Dec 24.
Premenstrual syndrome (PMS) might become severe enough to interfere with normal interpersonal relationships. This study was planned to assess whether administration of vitamin D (200,000 IU at first, followed by 25,000 IU every 2 weeks) for a 4-month period might lessen the appearance and the intensity of mood disorders associated with PMS in young girls with severe hypovitaminosis D. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: One hundred fifty-eight young girls (15-21 years old) with PMS-related severe symptoms of the emotional and cognitive domains and low serum 25-hydroxycholecalciferol (25-OH-D) levels (≤10 ng/mL) were randomly assigned to two treatment groups and treated for 4 months with vitamin D (group 1; n = 80) or placebo (group 2; n = 78). Clinical and hormonal effects were compared between the two groups.
In patients from group 1, levels of vitamin D reached the normal range (35-60 ng/mL) after the first month and remained stable throughout the whole study. At the end of treatment, anxiety score decreased from 51 to 20 (P < .001 vs baseline); irritability score declined from 130 to 70 (P < .001 vs baseline). Crying easily and sadness decreased by a score of 41 and 51 to a score of 30 and 31, respectively (P < .001). For disturbed relationships, the score decreased from 150 to 70 (P < .001). Conversely, no appreciable changes were noted in symptom intensity from patients of group 2. The frequency of adverse events (nausea and constipation) was not different between participants of group 1 and group 2.
On the basis of the present findings, vitamin D therapy can be proposed as a safe, effective, and convenient method for improving the quality of life in young women with severe hypovitaminosis D and concomitant mood disorders associated with PMS.
经前综合征（PMS）可能严重到足以干扰正常的人际关系。本研究旨在评估对维生素D严重缺乏的年轻女孩给予维生素D（初始剂量200,000 IU，随后每2周25,000 IU）治疗4个月是否可减轻与PMS相关的情绪障碍的出现及严重程度。设计、地点、参与者、干预措施及主要结局指标：158名患有PMS相关情绪和认知领域严重症状且血清25-羟胆钙化醇（25-OH-D）水平较低（≤10 ng/mL）的年轻女孩（15 - 21岁）被随机分为两个治疗组，分别接受维生素D治疗4个月（第1组；n = 80）或安慰剂治疗（第2组；n = 78）。比较两组的临床和激素效应。
第1组患者在第1个月后维生素D水平达到正常范围（35 - 60 ng/mL），且在整个研究过程中保持稳定。治疗结束时，焦虑评分从51降至20（与基线相比，P <.001）；易怒评分从130降至70（与基线相比，P <.001）。易哭和悲伤评分分别从41和51降至30和31（P <.001）。对于人际关系困扰，评分从150降至70（P <.001）。相反，第2组患者的症状严重程度未观察到明显变化。第1组和第2组参与者不良事件（恶心和便秘）的发生频率无差异。
基于目前的研究结果，维生素D治疗可作为一种安全、有效且便捷的方法，用于改善维生素D严重缺乏且伴有与PMS相关情绪障碍的年轻女性的生活质量。
