单纯的缺血预处理真的能在移植过程中保护器官免受缺血再灌注损伤吗？

Can ischemic preconditioning alone really protect organs from ischemia reperfusion injury in transplantation.

作者信息

Huang Yuchuan, Shan Juan, Wang Chuan'en, Ma Jie, Li Dan, Li Li, Li Shengfu, Li Youping

机构信息

Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, PR China.

出版信息

Transpl Immunol. 2009 Jan;20(3):127-31. doi: 10.1016/j.trim.2008.08.002. Epub 2008 Aug 30.

DOI:10.1016/j.trim.2008.08.002

PMID:18761408

Abstract

Organ transplantation is the only choice for treatment of end-stage disease. The ischemia reperfusion injury (I/RI) occurring after cold ischemia is an unavoidable injury during transplantation, which is also one of the main causes of graft failure. Multiple mechanisms have been postulated to explain tissue injury that occurs after I/RI. It is well-known that ischemic preconditioning (IPC), a short period of ischemia followed by reperfusion, arouses the endogenous mechanism of protection against a sustained ischemic insult. Can ischemic preconditioning alone really protect organs from ischemia reperfusion injury in transplantation?

摘要

器官移植是终末期疾病治疗的唯一选择。冷缺血后发生的缺血再灌注损伤（I/RI）是移植过程中不可避免的损伤，也是移植物功能衰竭的主要原因之一。人们提出了多种机制来解释I/RI后发生的组织损伤。众所周知，缺血预处理（IPC），即短时间缺血后再灌注，可激活内源性保护机制以抵抗持续的缺血性损伤。单纯的缺血预处理真的能保护器官免受移植中的缺血再灌注损伤吗？