Niu Ying, Ye Qi-Fa
Research Center of Transplantation Medicine Engineering and Technology of National Health Ministry, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Jun;33(6):548-52.
The concept of "ischemic postconditioning" was first raised in 2002, and the following 5 year research shows that it can protect organs from reperfusion injury. Although the mechanism of ischemic postconditioning is similar to ischemic preconditioning in many ways, it still has its own characteristics. Reperfusion injury is an inevitable problem in organ transplantation. It may accelerate the function recovery of the transplants to lessen the reperfusion injury. So ischemic postconditioning may have a fine prospect in organ transplantation for its good controllability during reperfusion. This article is going to briefly introduce the distinct mechanisms of ischemic postconditioning to protect organs from reperfusion injury and approach the possibilities of its application in organ transplantation.
“缺血后处理”的概念于2002年首次提出，随后5年的研究表明，它可以保护器官免受再灌注损伤。尽管缺血后处理的机制在很多方面与缺血预处理相似，但仍有其自身特点。再灌注损伤是器官移植中不可避免的问题。减轻再灌注损伤可能会加速移植器官功能的恢复。因此，缺血后处理因其在再灌注过程中良好的可控性，在器官移植中可能具有良好的应用前景。本文将简要介绍缺血后处理保护器官免受再灌注损伤的独特机制，并探讨其在器官移植中的应用可能性。
