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PI3K进入beta测试阶段。

PI3K enters beta-testing.

作者信息

Shaywitz Adam J, Courtney Kevin D, Patnaik Akash, Cantley Lewis C

机构信息

Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

出版信息

Cell Metab. 2008 Sep;8(3):179-81. doi: 10.1016/j.cmet.2008.08.011.

Abstract

Phosphoinositide-3-OH kinases (PI3K) are critical regulators of cell metabolism, growth, and survival. In a recent publication in Nature, Jia et al. (2008) identify specific functions of the p110beta isoform of PI3K in glucose metabolism, cellular proliferation, and tumorigenesis.

摘要

磷酸肌醇-3-羟基激酶(PI3K)是细胞代谢、生长和存活的关键调节因子。在最近发表于《自然》杂志的一篇论文中,贾等人(2008年)确定了PI3K的p110β亚型在葡萄糖代谢、细胞增殖和肿瘤发生中的特定功能。

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本文引用的文献

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Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.
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The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
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