磷脂酰肌醇3激酶作为生长和代谢调节因子的演变

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.

作者信息

Engelman Jeffrey A, Luo Ji, Cantley Lewis C

机构信息

Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

Nat Rev Genet. 2006 Aug;7(8):606-19. doi: 10.1038/nrg1879.

DOI:10.1038/nrg1879

PMID:16847462

Abstract

Phosphatidylinositol 3-kinases (PI3Ks) evolved from a single enzyme that regulates vesicle trafficking in unicellular eukaryotes into a family of enzymes that regulate cellular metabolism and growth in multicellular organisms. In this review, we examine how the PI3K pathway has evolved to control these fundamental processes, and how this pathway is in turn regulated by intricate feedback and crosstalk mechanisms. In light of the recent advances in our understanding of the function of PI3Ks in the pathogenesis of diabetes and cancer, we discuss the exciting therapeutic opportunities for targeting this pathway to treat these diseases.

摘要

磷脂酰肌醇3激酶（PI3Ks）从一种调节单细胞真核生物中囊泡运输的单一酶进化而来，成为调节多细胞生物细胞代谢和生长的一类酶。在本综述中，我们研究了PI3K信号通路是如何进化以控制这些基本过程的，以及该信号通路又是如何反过来受到复杂的反馈和串扰机制调节的。鉴于我们对PI3Ks在糖尿病和癌症发病机制中功能的理解取得了最新进展，我们讨论了针对该信号通路治疗这些疾病所带来的令人兴奋的治疗机会。