Gedevanishvili G I
Laboratory of the General Physiology of the Cerebral Cortex, I.S. Beritashvili Institute of Physiology, Academy of Sciences of the GSSR [AN GSSR], Tbilisi.
Neurosci Behav Physiol. 1991 Mar-Apr;21(2):130-5. doi: 10.1007/BF01182888.
The influence of a series of muscarinic (M) and nicotinic (N) substances on the dendritic potentials of the cerebral cortex was studied in acute experiments on adult cats under deep nembutal anesthesia. M-Antagonists in large doses and M-agonists, N-agonists and acetylcholine elicited a decrease in the amplitude of dendritic potentials. M-Antagonists in small doses and N-antagonists elicited an increase in the amplitude of the dendritic potentials. The application of an anticholinesterase substance, proserine, to the cortex elicited an increase in the amplitude and duration of the dendritic potentials. It is hypothesized that there are postsynaptic M-cholinoreceptors of the M1 type, presynaptic M-cholinoreceptors of the M2 type, and presynaptic N-cholinoreceptors in the neuropil of layer I of the cortex.
在深度戊巴比妥麻醉下，对成年猫进行急性实验，研究了一系列毒蕈碱（M）和烟碱（N）物质对大脑皮质树突电位的影响。大剂量M拮抗剂、M激动剂、N激动剂和乙酰胆碱可使树突电位幅度降低。小剂量M拮抗剂和N拮抗剂可使树突电位幅度增加。向皮质应用抗胆碱酯酶物质毒扁豆碱可使树突电位的幅度和持续时间增加。据推测，在皮质I层神经毡中存在M1型突触后M胆碱能受体、M2型突触前M胆碱能受体和突触前N胆碱能受体。
