Wada Yasuo, Harada Nobuko, Ohara Kazuhiro, Kawata Hironori, Iwasaki Hironori, Kawamura Yuuichiro, Gomi Takashi, Ohtoshi Masahiro, Nakashima Yasuaki
Department of Surgery, NHO Himeji Medical Center, 68 Honmachi, Himeji, Hyogo, 670-8520, Japan.
Breast Cancer. 2009;16(2):151-6. doi: 10.1007/s12282-008-0068-6. Epub 2008 Sep 2.
Esophageal metastasis from primary breast cancer is an unusual manifestation. We recently treated a patient with dysphagia, whose breast cancer had been treated in the distant past. A 70-year-old woman had been followed regularly in our outpatient clinic for 14 years after her primary breast cancer treatment, with no apparent tumor recurrence. After 2 years absence, she consulted our clinic with progressive dysphagia. Contrast esophagography and endoscopic examination with ultrasonography revealed a protruding submucosal tumor that was histopathologically diagnosed as esophageal metastasis of breast cancer. Radiation therapy involving a total of 60 Gy in combination with aromatase inhibitor was given. The patient's dysphagia was greatly relieved, concomitant with marked improvement of the stenotic lesion on imaging. Since treatment for recurrent breast cancer is generally palliative, systemic (chemo- and/or endocrine-) therapy in combination with radiotherapy is the first-line option for esophageal metastasis of breast cancer.
原发性乳腺癌的食管转移是一种不常见的表现。我们最近治疗了一名吞咽困难的患者，其乳腺癌在很久以前就已接受过治疗。一名70岁女性在接受原发性乳腺癌治疗后，在我们门诊定期随访了14年，无明显肿瘤复发。在缺席2年后，她因进行性吞咽困难前来就诊。食管造影和超声内镜检查发现一个突出的黏膜下肿瘤，经组织病理学诊断为乳腺癌食管转移。给予了总计60 Gy的放射治疗并联合芳香化酶抑制剂。患者的吞咽困难得到极大缓解，影像学上狭窄病变也有明显改善。由于复发性乳腺癌的治疗通常是姑息性的，全身（化疗和/或内分泌）治疗联合放疗是乳腺癌食管转移的一线选择。
