Ozdemir Nuriye Yildirim, Abali Hüseyin, Oksüzoğlu Berna, Budakoğlu Burçin, Akmangit Ilkay, Zengin Nurullah
Medical Oncology Clinic, Ministry of Health Ankara Numune Research and Training Hospital, Ankara, Turkey.
Support Care Cancer. 2009 Apr;17(4):399-403. doi: 10.1007/s00520-008-0498-x. Epub 2008 Sep 2.
It is generally recommended to wait for at least 24 h before starting chemotherapy after implanting venous port catheters (VPC). Our aim was to evaluate whether it is safe to start chemotherapy on the day of implantation.
One hundred eighty patients who had to be given chemotherapy on the day of VPC implantation at our institution from June 2005 to April 2007 were included.
Of patients, 122 were male (67.8%) and median age was 55 years. Majority (133, 72.8%) had colon and gastric adenocancer. Median time to chemotherapy onset from VPC implantation was 102 min (minimum-maximum, 12-402). One hundred sixty-four (91.1%) received prolonged chemotherapy infusions beyond 48 h. No life-threatening acute complications like pneumothorax and hemothorax developed. In one patient extravasation (empty saline extravasation secondary to wrong insertion of the needle), in 17 (9.4%) pain, and in 41 (22.8%) minor bleeding as echymosis were seen. Thrombosis developed in 11 (6.1%). Reasons for VPC removal were thrombosis (2), sepsis (2), cellulitis (1), skin dehiscence (1), and patient will (1).
Chemotherapy administration immediately after VPC implantation appears safe without increased acute and chronic complications in inpatient setting.
一般建议在植入静脉港导管（VPC）后至少等待24小时再开始化疗。我们的目的是评估在植入当天开始化疗是否安全。
纳入了2005年6月至2007年4月在我院必须在VPC植入当天接受化疗的180例患者。
患者中，122例为男性（67.8%），中位年龄为55岁。大多数（133例，72.8%）患有结肠和胃腺癌。从VPC植入到开始化疗的中位时间为102分钟（最短 - 最长，12 - 402分钟）。164例（91.1%）接受了超过48小时的延长化疗输注。未发生危及生命的急性并发症，如气胸和血胸。1例患者发生外渗（因针头误插导致空盐水外渗），17例（9.4%）出现疼痛，41例（22.8%）出现轻微出血如瘀斑。11例（6.1%）发生血栓形成。VPC移除的原因有血栓形成（2例）、败血症（2例）、蜂窝织炎（1例）、皮肤裂开（1例）和患者意愿（1例）。
在住院环境中，VPC植入后立即进行化疗似乎是安全的，不会增加急性和慢性并发症。
