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[人类机体功能系统适应性障碍在长期滞留南极地区期间对基因HIF-1α多态性的依赖性]

[Dependence of adaptative disorders of the human organism functional systems on gene HIF-1alpha polymorphism during long stay in Antarctic region].

作者信息

Moiseienko Ie V, Drevyts'ka T I

出版信息

Fiziol Zh (1994). 2008;54(3):65-73.

PMID:18763582
Abstract

The investigation was carried out on 45 men aged 43.1 +/- 2.9 years which were team members of the Antarctic station Academician Vernadsky. Among participants of expedition, we revealed 22% of winterers with the heterozygotic genotype C/T HIF-1alpha. It was shown that the persons with a heterozygotic genotype were more predisposed to the latent hypoxia development during long stay in Antarctica.

摘要

该调查针对45名年龄在43.1±2.9岁的男性进行，他们是韦尔纳茨基院士南极站的队员。在探险参与者中，我们发现22%的越冬者具有杂合基因型C/T HIF-1α。结果表明，具有杂合基因型的人在长期滞留南极期间更容易发生潜在性缺氧。

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引用本文的文献

1
Antarctica challenges the new horizons in predictive, preventive, personalized medicine: preliminary results and attractive hypotheses for multi-disciplinary prospective studies in the Ukrainian "Akademik Vernadsky" station.南极洲挑战预测、预防、个性化医学新视野：乌克兰“弗纳德斯基院士”站多学科前瞻性研究的初步结果与诱人假设
EPMA J. 2016 May 31;7(1):11. doi: 10.1186/s13167-016-0060-8. eCollection 2016.