Fiziol Zh (1994). 2012;58(4):13-20.
The features of the distribution of allelic variants Pro582-->Ser polymorphism in HIF-1alpha gene in groups of athletes involved in sports, with different types of compensatory mechanisms of adaptation to hypoxic stress were investigated. During the study 191 highly qualified athletes were examined. The control group included 260 subjects, not engaged in sports. The possibility of using this polymorphism as a molecular genetic marker of susceptibility to a variety of sports pursuits. The distribution of allelic variants of HIF-1alpha Pro582-->Ser polymorphism of the residents of Ukraine was investigated. Found that the Pro/Pro genotype contributes to endurance performance. It is shown that the 582Ser gene HIF-1alpha is a marker of predisposition to power sports. The result revealed that the frequency of Ser allele of HIF-1alpha (16% vs 7%, P=0.03) was significantly higher in the power-orientated athletes compared to endurance athletes.
研究了参与不同类型低氧应激适应补偿机制运动项目的运动员群体中，低氧诱导因子-1α（HIF-1α）基因Pro582→Ser多态性等位基因变体的分布特征。研究期间对191名高水平运动员进行了检查。对照组包括260名不从事体育运动的受试者。探讨了将这种多态性用作各种体育项目易感性分子遗传标记的可能性。研究了乌克兰居民HIF-1α Pro582→Ser多态性等位基因变体的分布。发现Pro/Pro基因型有助于耐力表现。结果表明，HIF-1α的582Ser基因是力量型运动易感性的标志物。结果显示，与耐力型运动员相比，力量型运动员中HIF-1α的Ser等位基因频率显著更高（16%对7%，P = 0.03）。
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