Sinclair Alex, Stockman Robert A
School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, NR4 7TJ, UK.
Nat Prod Rep. 2007 Apr;24(2):298-326. doi: 10.1039/b604203c. Epub 2007 Feb 21.
This article brings together for the first time reviews of all the synthetic attempts towards the spirocyclic histrionicotoxin alkaloids published since the discovery of the group in 1971. This covers 5 total syntheses of the fully unsaturated parent alkaloid HTX-283A, 7 total syntheses of perhydrohistrionicotoxin, 15 total syntheses of other members of this alkaloid family, 25 formal syntheses, and 19 partial syntheses involving the successful formation of the core azaspirocyclic structure but lacking advancement towards the target structure.
本文首次汇集了自1971年发现该类螺环组织胺毒素生物碱以来，所有关于其合成尝试的综述。这涵盖了全不饱和母体生物碱HTX - 283A的5次全合成、全氢组织胺毒素的7次全合成、该生物碱家族其他成员的15次全合成、25次形式合成以及19次部分合成，其中部分合成成功形成了核心氮杂螺环结构，但在向目标结构推进方面有所欠缺。
