心力衰竭中的解偶联蛋白
Uncoupling proteins in heart failure.
作者信息
Laskowski Karl R, Russell Raymond R
出版信息
Curr Heart Fail Rep. 2008 Jun;5(2):75-9. doi: 10.1007/s11897-008-0013-1.
Abstract
The development of heart failure is associated with alterations in the expression of a wide variety of structural, signaling, and metabolic proteins. One such effect is the downregulation of uncoupling proteins in the setting of heart failure. This group of proteins regulates the mitochondrial membrane potential and therefore plays a role in mitochondrial energy metabolism as well as reactive oxygen species generation by the mitochondria. This review discusses the role of uncoupling proteins in regulating oxidant stress and implications with respect to the pathogenesis of heart failure and potential treatments.
摘要
心力衰竭的发展与多种结构、信号和代谢蛋白的表达改变有关。其中一种效应是在心力衰竭情况下解偶联蛋白的下调。这组蛋白调节线粒体膜电位，因此在线粒体能量代谢以及线粒体产生活性氧方面发挥作用。本综述讨论了解偶联蛋白在调节氧化应激中的作用以及对心力衰竭发病机制和潜在治疗的影响。
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