线粒体解偶联蛋白的调控与周转
The regulation and turnover of mitochondrial uncoupling proteins.
作者信息
Azzu Vian, Jastroch Martin, Divakaruni Ajit S, Brand Martin D
机构信息
Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
出版信息
Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):785-91. doi: 10.1016/j.bbabio.2010.02.035. Epub 2010 Mar 6.
Abstract
Uncoupling proteins (UCP1, UCP2 and UCP3) are important in regulating cellular fuel metabolism and as attenuators of reactive oxygen species production through strong or mild uncoupling. The generic function and broad tissue distribution of the uncoupling protein family means that they are increasingly implicated in a range of pathophysiological processes including obesity, insulin resistance and diabetes mellitus, neurodegeneration, cardiovascular disease, immunity and cancer. The significant recent progress describing the turnover of novel uncoupling proteins, as well as current views on the physiological roles and regulation of UCPs, is outlined.
摘要
解偶联蛋白（UCP1、UCP2和UCP3）在调节细胞燃料代谢以及通过强解偶联或弱解偶联作为活性氧生成的衰减剂方面具有重要作用。解偶联蛋白家族的一般功能和广泛的组织分布意味着它们越来越多地涉及一系列病理生理过程，包括肥胖、胰岛素抵抗和糖尿病、神经退行性变、心血管疾病、免疫和癌症。本文概述了描述新型解偶联蛋白更新的近期重大进展以及关于UCPs生理作用和调节的当前观点。
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