Burns A, Lewis G, Jacoby R, Levy R
Section of Old Age Psychiatry, Institute of Psychiatry, London.
Psychol Med. 1991 May;21(2):363-70. doi: 10.1017/s0033291700020468.
Factors affecting survival of 178 patients diagnosed using NINCDS/ADRDA criteria for Alzheimer's disease were studied. All patients were drawn from the Camberwell Health Authority Area and so were a representative sample of subjects from a clinical old age psychiatry service. The mortality rate of the sample was 3.5 times that expected after adjustment for age. Younger subjects had a higher standardized mortality ratio than older subjects. The cumulative three-year mortality of the sample was 47%. Factors shown to be associated with a reduced survival included: increasing age, longer duration of illness, male sex, presence of physical illness, poor cognitive function, observed depression and absence of misidentification syndromes. Apraxia was a stronger predictor of early death than aphasia or dysmnesia.
研究了影响178例根据美国国立神经疾病与中风研究所/阿尔茨海默病及相关疾病协会（NINCDS/ADRDA）标准诊断为阿尔茨海默病患者生存的因素。所有患者均来自坎伯韦尔卫生管理局辖区，因此是临床老年精神病学服务对象的代表性样本。经年龄调整后，该样本的死亡率是预期死亡率的3.5倍。年轻受试者的标准化死亡率高于老年受试者。该样本的三年累积死亡率为47%。已表明与生存时间缩短相关的因素包括：年龄增加、病程延长、男性、存在躯体疾病、认知功能差、观察到的抑郁以及不存在错认综合征。失用症比失语症或记忆障碍更能预测早期死亡。
