Department of Neurology, The Huangpu Branch of Shanghai No. 9 People's Hospital, 56695Shanghai Jiao Tong University Medical School, Shanghai, PR China.
Department of Gerontology, Shanghai No. 9 People's Hospital, 56695Shanghai Jiao Tong University Medical School, Shanghai, PR China.
Am J Alzheimers Dis Other Demen. 2022 Jan-Dec;37:15333175221115247. doi: 10.1177/15333175221115247.
The AD7c-NTP is a promising biomarker for AD diagnosis. However, the exact urinary AD7c-NTP concentration to differentiate AD from the mild cognitive impairment (MCI) remains inconclusive. We enrolled 98 and 90 clinical defined AD and MCI patients, respectively, and access their cognition impairment with Neuropsychiatric Inventory (NPI) and Mental State Examination (MMSE) along with their urinary AD7c-NTP. We demonstrated that urinary AD7c-NTP level in sequence from high to low was AD, MCI, and healthy groups ( < .01), and the AD7c-NTP was positively and negatively correlated with the NPI and MMSE scores, respectively. Additionally, AD7c-NTP well-matched NPI subscale scores, including agitation, depression, and apathy ( < .05). Importantly, the optimal cut-off AD7c-NTP level to distinguish the AD and MCI was .94 ng/mL (sensitivity 85.71% & specificity 73.91%). Conclusively, urinary AD7c-NTP could be used for cognition impairment evaluation and differentiated diagnosis of AD and MCI.
AD7c-NTP 是一种很有前途的 AD 诊断生物标志物。然而，用于区分 AD 与轻度认知障碍（MCI）的确切尿 AD7c-NTP 浓度仍不确定。我们分别招募了 98 名和 90 名临床确诊的 AD 和 MCI 患者，并通过神经精神问卷（NPI）和精神状态检查（MMSE）评估他们的认知障碍，同时检测他们的尿 AD7c-NTP。结果显示，尿 AD7c-NTP 水平从高到低依次为 AD、MCI 和健康组（<0.01），AD7c-NTP 与 NPI 和 MMSE 评分分别呈正相关和负相关。此外，AD7c-NTP 与 NPI 的多个亚量表评分（包括激越、抑郁和淡漠）具有良好的匹配性（<0.05）。重要的是，区分 AD 和 MCI 的最佳 AD7c-NTP 截断值为 0.94ng/mL（灵敏度 85.71%，特异性 73.91%）。综上，尿 AD7c-NTP 可用于认知障碍评估及 AD 和 MCI 的鉴别诊断。
