Condon John R, Rumbold Alice R, Thorn Jane C, O'Brien Margaret M, Davy Margaret J, Zardawi Ibrahim
Services, Systems and Society Division, Menzies School of Health Research, PO Box 41096, Casuarina, NT, 0811, Australia.
Cancer Causes Control. 2009 Feb;20(1):67-74. doi: 10.1007/s10552-008-9218-6. Epub 2008 Sep 3.
To describe the epidemiological features of a possible disease cluster of vulvar cancer and pre-cancers in Australian Indigenous women living in the Northern Territory (NT) of Australia.
We identified NT-resident women with a confirmed histological diagnosis of vulvar cancer or high-grade vulvar intraepithelial neoplasia (VIN) between 1 January 1996 and 31 December 2005.
Seventy-one women were identified; 32 diagnosed with vulvar cancer and 39 with high-grade VIN. Most women diagnosed were Indigenous, aged less than 50 years and living in remote communities in the East Arnhem (EA) district, on the north-east coast of the NT. The age-adjusted incidence rate of vulvar cancer in EA Indigenous women aged 0-49 years was 31.1 per 100,000 (95% CI 13.1-49.1), over 50 times higher than the national Australian rate (0.4 per 100,000, 95% CI 0.4-0.5) for the same age-group. In the age-group of 0-49 years, the age-adjusted incidence rate of VIN for EA Indigenous women was 34.7 per 100,000 (95% CI 15.2-54.3), compared with 6.7 per 100,000 (95% CI 2.0-11.4) for Indigenous women living elsewhere in the Top End of the NT.
These data provide evidence of a geographic cluster of vulvar cancer in remote Indigenous communities in northern Australia.
描述居住在澳大利亚北领地（NT）的澳大利亚原住民女性中可能存在的外阴癌及癌前病变疾病聚集的流行病学特征。
我们确定了1996年1月1日至2005年12月31日期间在NT居住且经组织学确诊为外阴癌或高级别外阴上皮内瘤变（VIN）的女性。
共确定了71名女性；其中32例诊断为外阴癌，39例为高级别VIN。大多数被诊断的女性为原住民，年龄小于50岁，居住在NT东北海岸东阿纳姆（EA）区的偏远社区。EA地区0至49岁原住民女性外阴癌的年龄调整发病率为每100,000人中有31.1例（95%置信区间13.1 - 49.1），比澳大利亚同年龄组的全国发病率（每100,000人中有0.4例，95%置信区间0.4 - 0.5）高出50多倍。在0至49岁年龄组中，EA原住民女性VIN的年龄调整发病率为每100,000人中有34.7例（95%置信区间15.2 - 54.3），而居住在NT顶端其他地区的原住民女性为每100,000人中有6.7例（95%置信区间2.0 - 11.4）。
这些数据为澳大利亚北部偏远原住民社区中存在外阴癌地理聚集现象提供了证据。
