Peleg B A, Heller E D, Pitkovsky J
Kimron Veterinary Institute, Bet Dagan, Israel.
Avian Pathol. 1985 Oct;14(4):471-81. doi: 10.1080/03079458508436250.
The ontogeny of the humoral immune response to sheep red blood cells (SRBC), a non-infective antigen, and to killed Escherichia coli (E. coli), a disease-related antigen, was compared in young chicks of three poultry populations: a White Leghorn layer strain and two strains of White Rock broiler breeders. SRBC were injected intravenously into randomly selected groups of chicks every 3 days from hatch until 42 days. In separate groups of chicks, E. coli (1 x 10(8) heat-inactivated organisms) were injected intravenously over the same age range. A clear difference was found in the response pattern to the two antigens with age. The response to SRBC developed rapidly: at 6 days 'of age most chicks showed measurable antibody titres. The response to E. coli developed more slowly: at 6 days of age most of the chicks in the three strains tested did not show measurable antibody titres. The age response pattern of the two White Rock strains tended to be similar to one another and to differ from the response of the White Leghorn strain. Considerable variation in antibody titre was found within each group of chicks. These results indicate that differences are present in the rate of development of the immune response to different antigens and suggest that genetic differences in the rate of development of the immune response to a given antigen may be present both between and within poultry populations. Thus, increasing the rate of development of the immune response in poultry populations may be a feasible breeding objective.
在三个家禽群体的幼雏中，比较了对绵羊红细胞（SRBC，一种非感染性抗原）和对灭活大肠杆菌（E. coli，一种与疾病相关的抗原）的体液免疫反应的个体发生情况。这三个家禽群体分别是一个白来航蛋鸡品系和两个白洛克肉鸡育种品系。从雏鸡出壳到42日龄，每隔3天给随机挑选的雏鸡组静脉注射SRBC。在另一组雏鸡中，在相同的年龄范围内静脉注射E. coli（1×10⁸ 热灭活菌）。结果发现，随着年龄增长，对这两种抗原的反应模式存在明显差异。对SRBC的反应发展迅速：6日龄时，大多数雏鸡显示出可测量的抗体滴度。对E. coli的反应发展较慢：6日龄时，所测试的三个品系中的大多数雏鸡未显示出可测量的抗体滴度。两个白洛克品系的年龄反应模式彼此相似，且与白来航品系的反应不同。在每组雏鸡中发现抗体滴度存在相当大的差异。这些结果表明，对不同抗原的免疫反应发展速度存在差异，并表明在对给定抗原的免疫反应发展速度方面，家禽群体之间和群体内部可能存在遗传差异。因此，提高家禽群体免疫反应的发展速度可能是一个可行的育种目标。
