眼表黏蛋白在健康与疾病中的功能。
Functions of ocular surface mucins in health and disease.
作者信息
Mantelli Flavio, Argüeso Pablo
机构信息
Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA.
出版信息
Curr Opin Allergy Clin Immunol. 2008 Oct;8(5):477-83. doi: 10.1097/ACI.0b013e32830e6b04.
Abstract
PURPOSE OF REVIEW
The purpose of the present review is to describe new concepts on the role of mucins in the protection of corneal and conjunctival epithelia and to identify alterations of mucins in ocular surface diseases.
RECENT FINDINGS
New evidence indicates that gel-forming and cell surface-associated mucins contribute differently to the protection of the ocular surface against allergens, pathogens, extracellular molecules, abrasive stress, and drying.
SUMMARY
Mucins are high-molecular weight glycoproteins characterized by their extensive O-glycosylation. Major mucins expressed by the ocular surface epithelia include cell surface-associated mucins MUC1, MUC4, MUC16, and the gel-forming mucin MUC5AC. Recent advances using functional assays have allowed the examination of their roles in the protection of corneal and conjunctival epithelia. Alterations in mucin and mucin O-glycan biosynthesis in ocular surface disorders, including allergy, nonautoimmune dry eye, autoimmune dry eye, and infection, are presented.
摘要
综述目的
本综述旨在描述黏蛋白在保护角膜和结膜上皮方面作用的新概念，并确定眼表疾病中黏蛋白的改变。
最新发现
新证据表明，凝胶形成型和细胞表面相关黏蛋白在保护眼表免受过敏原、病原体、细胞外分子、摩擦应激和干燥影响方面发挥着不同作用。
总结
黏蛋白是高分子量糖蛋白，其特征在于广泛的O-糖基化。眼表上皮表达的主要黏蛋白包括细胞表面相关黏蛋白MUC1、MUC4、MUC16，以及凝胶形成型黏蛋白MUC5AC。利用功能测定的最新进展使得能够研究它们在保护角膜和结膜上皮中的作用。本文介绍了眼表疾病（包括过敏、非自身免疫性干眼、自身免疫性干眼和感染）中黏蛋白和黏蛋白O-聚糖生物合成的改变。
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