Dulak Jozef, Loboda Agnieszka, Jozkowicz Alicja
Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Curr Opin Lipidol. 2008 Oct;19(5):505-12. doi: 10.1097/MOL.0b013e32830d81e9.
Heme oxygenase-1 apart from converting heme to carbon monoxide, iron and biliverdin has been shown to exert anti-inflammatory, antiapoptotic and antioxidant actions. The present review summarizes the most recent studies about heme oxygenase-1 involvement in atherosclerosis, neovascularization and endothelial progenitor cells biology.
Heme oxygenase-1 has been shown to be protective against atherosclerosis via decreasing ROS generation and proinflammatory cytokine production resulting in diminished lipid uptake and foam cell formation. Moreover, heme oxygenase-1 role in neovascularization and its involvement in response of endothelial progenitor cells to stromal cell derived factor-1 as well as endothelial cells to vascular endothelial growth factor has been stressed, recently. The detailed mechanisms of heme oxygenase-1 action in the processes of vasculogenesis and angiogenesis as well as the involvement of Nrf2 and KLF2 transcription factors in heme oxygenase-1-dependent vascular protection are among the subjects most intensively studied, currently.
Recent studies underscore the critical role of heme oxygenase-1 in neovascularization, implicating heme oxygenase-1 as an attractive therapeutic target for treatment of cardiovascular disease.
除了将血红素转化为一氧化碳、铁和胆绿素外，血红素加氧酶-1还具有抗炎、抗凋亡和抗氧化作用。本综述总结了关于血红素加氧酶-1参与动脉粥样硬化、新生血管形成和内皮祖细胞生物学的最新研究。
血红素加氧酶-1已被证明可通过减少活性氧生成和促炎细胞因子产生来预防动脉粥样硬化，从而减少脂质摄取和泡沫细胞形成。此外，最近强调了血红素加氧酶-1在新生血管形成中的作用及其参与内皮祖细胞对基质细胞衍生因子-1的反应以及内皮细胞对血管内皮生长因子的反应。目前，血红素加氧酶-1在血管生成和血管新生过程中的详细作用机制以及Nrf2和KLF2转录因子参与血红素加氧酶-1依赖性血管保护是研究最深入的课题之一。
最近的研究强调了血红素加氧酶-1在新生血管形成中的关键作用，这表明血红素加氧酶-1是治疗心血管疾病的一个有吸引力的治疗靶点。
