Chen Xiaopeng, Hu Yongcheng, Fang Cheng, Zhang Rongxin, Wang Han, He Xin, Yuan Binbin
Graduate Department of Tianjin Medical University, Tianjin 300070, PR China.
Department of Bone and Soft Tissue Tumor, Tianjin Hospital, PR China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2013 Oct;27(10):1256-61.
To review the latest research progress of heme oxygenase 1 (HO-1), to thoroughly understand different functions of HO-1 and its influence on osteogenesis and angiogenesis of stem cells, and to analyze HO-1 application in bone tissue engineering.
Domestic and international literature on HO-1 in recent years was extensively reviewed and analyzed.
The activity of HO-1 and its enzymatic products not only have the properties of anti-inflammatory, anti-apoptosis, and cytoprotection, but also can promote angiogenesis combined with other growth factors and protect the vessel which already exist. Moreover, HO-1 has an effect on the proliferation, paracrine signaling, osteoblastic differentiation, and anti-apoptosis of stem cells.
HO-1 can be used as a multi-function growth factor in bone tissue engineering, but more investigation should emphasis on synergistic effect of each function so as to improve bone repair.
综述血红素加氧酶1（HO-1）的最新研究进展，深入了解HO-1的不同功能及其对干细胞成骨和血管生成的影响，并分析HO-1在骨组织工程中的应用。
广泛查阅并分析近年来国内外关于HO-1的文献。
HO-1的活性及其酶促产物不仅具有抗炎、抗凋亡和细胞保护特性，还能与其他生长因子联合促进血管生成并保护已存在的血管。此外，HO-1对干细胞的增殖、旁分泌信号传导、成骨细胞分化及抗凋亡均有作用。
HO-1可作为骨组织工程中的多功能生长因子，但应更多关注各功能的协同效应以改善骨修复。
