中国一株主要传染性支气管炎病毒（IBV）毒株的全基因组序列分析
Complete genome sequence analysis of a predominant infectious bronchitis virus (IBV) strain in China.
作者信息
Liu Xing-Li, Su Jing-Liang, Zhao Ji-Xun, Zhang Guo-Zhong
机构信息
Department of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China.
出版信息
Virus Genes. 2009 Feb;38(1):56-65. doi: 10.1007/s11262-008-0282-5. Epub 2008 Sep 3.
Infectious bronchitis (IB) is one of the major diseases in poultry flocks all over the world caused by infectious bronchitis virus (IBV). In the study, the complete genome sequence of strain A2 was sequenced and analyzed, which was a predominant IBV strain in China. The results indicated that there were mutations, insertions, and deletions distributed in the whole genome. The A2 virus had the highest identity to S14 and BJ in terms of full genome, whereas had a further distance to Massachusetts strains. Phylogenetic analysis showed that A2 isolate clustered together with most Chinese strains. The results of this study suggest that strain A2 may play an important role in IBV's evolution and A2-like IBVs are predominant strains in China.
传染性支气管炎（IB）是由传染性支气管炎病毒（IBV）引起的全球家禽群中的主要疾病之一。在本研究中，对中国流行的一株A2传染性支气管炎病毒（IBV）毒株进行了全基因组测序及分析。结果表明，该毒株全基因组存在多处突变、插入和缺失。全基因组比对结果显示，A2毒株与S14和BJ毒株亲缘关系最近，与Massachusetts毒株亲缘关系较远。进化树分析表明，A2毒株与大多数中国分离株聚集在一起。本研究结果表明，A2毒株可能在IBV的进化中发挥重要作用，且A2样IBV毒株是中国的优势毒株。
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