Gehring U, Strikwold M, Schram-Bijkerk D, Weinmayr G, Genuneit J, Nagel G, Wickens K, Siebers R, Crane J, Doekes G, Di Domenicantonio R, Nilsson L, Priftanji A, Sandin A, El-Sharif N, Strachan D, van Hage M, von Mutius E, Brunekreef B
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Clin Exp Allergy. 2008 Dec;38(12):1911-20. doi: 10.1111/j.1365-2222.2008.03087.x.
Several studies have consistently reported inverse associations between exposure to endotoxin in house dust and atopy. With regard to the association between house dust endotoxin and asthma, the results are inconsistent.
To study the association between house dust endotoxin levels and respiratory symptoms and atopy in populations from largely different countries.
Data were collected within the International Study on Asthma and Allergies in Childhood Phase Two, a multi-centre cross-sectional study of 840 children aged 9-12 years from six centres in the five countries of Albania, Italy, New Zealand, Sweden and the United Kingdom. Living room floor dust was collected and analysed for endotoxin. Health end-points and demographics were assessed by standardized questionnaires. Atopy was assessed by measurements of allergen-specific IgE against a panel of inhalant allergens. Associations between house dust endotoxin and health outcomes were analysed by logistic regression. Odds ratios (ORs) were presented for an overall interquartile range increase in exposure.
Many associations between house dust endotoxin in living room floor dust and health outcomes varied between countries. Combined across countries, endotoxin levels were inversely associated with asthma ever [adjusted OR (95% confidence interval (CI)) 0.53 (0.29-0.96) for endotoxin levels per m(2) of living room floor] and current wheeze [adjusted OR (95% CI) 0.77 (0.64-0.93) for endotoxin levels per gram of living room floor dust]. There were inverse associations between endotoxin concentrations and atopy, which were statistically significant in unadjusted analyses, but not after adjustment for gender, parental allergies, cat and house dust mite allergens. No associations were found with dust quantity and between endotoxin exposure and hayfever.
These findings suggest an inverse association between endotoxin levels in living room floor dust and asthma in children.
多项研究一致报告称，室内灰尘中的内毒素暴露与特应性之间存在负相关。关于室内灰尘内毒素与哮喘之间的关联，结果并不一致。
研究来自不同国家人群的室内灰尘内毒素水平与呼吸道症状及特应性之间的关联。
数据收集于儿童哮喘和过敏国际研究的第二阶段，这是一项多中心横断面研究，涉及来自阿尔巴尼亚、意大利、新西兰、瑞典和英国五个国家六个中心的840名9至12岁儿童。收集客厅地板灰尘并分析其中的内毒素。通过标准化问卷评估健康终点和人口统计学特征。通过测量针对一组吸入性过敏原的过敏原特异性IgE来评估特应性。通过逻辑回归分析室内灰尘内毒素与健康结果之间的关联。呈现暴露总体四分位间距增加时的比值比（OR）。
客厅地板灰尘中的室内灰尘内毒素与健康结果之间的许多关联在不同国家有所不同。综合各国情况，内毒素水平与曾经患哮喘呈负相关[每平方米客厅地板内毒素水平的调整后OR（95%置信区间[CI]）为0.53（0.29 - 0.96）]，与当前喘息呈负相关[每克客厅地板灰尘内毒素水平的调整后OR（95%CI）为0.77（0.64 - 0.93）]。内毒素浓度与特应性之间存在负相关，在未调整分析中具有统计学意义，但在调整性别、父母过敏、猫和屋尘螨过敏原后无统计学意义。未发现与灰尘量以及内毒素暴露与花粉症之间存在关联。
这些发现表明客厅地板灰尘中的内毒素水平与儿童哮喘之间存在负相关。
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