Wolf Molly, Lai Peggy S
Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Bulfinch 148, Boston, MA 02114, USA.
Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Bulfinch 148, Boston, MA 02114, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Clin Chest Med. 2020 Dec;41(4):777-796. doi: 10.1016/j.ccm.2020.08.005.
Effects of environmental microbial exposures on human health have long been of interest. Microbes were historically assumed to be harmful, but data have suggested that microbial exposures can modulate the immune system. We focus on the effects of indoor environmental microbial exposure on chronic lung diseases. We found contradictory data in bacterial studies using endotoxin as a surrogate for bacterial exposure. Contradictory data also exist in studies of fungal exposure. Many factors may modulate the effect of environmental microbial exposures on lung health, including coexposures. Future studies need to clarify which method of assessing environmental microbial exposures is most relevant.
长期以来，环境微生物暴露对人类健康的影响一直备受关注。从历史上看，微生物被认为是有害的，但数据表明，微生物暴露可以调节免疫系统。我们关注室内环境微生物暴露对慢性肺部疾病的影响。我们在使用内毒素作为细菌暴露替代物的细菌研究中发现了相互矛盾的数据。在真菌暴露研究中也存在相互矛盾的数据。许多因素可能会调节环境微生物暴露对肺部健康的影响，包括共同暴露。未来的研究需要明确哪种评估环境微生物暴露的方法最具相关性。
