1型糖尿病合并血管病变女性的子宫内生长异常关联
The association of intrauterine growth abnormalities in women with type 1 diabetes mellitus complicated by vasculopathy.
作者信息
Haeri Sina, Khoury Jane, Kovilam Oormila, Miodovnik Menachem
机构信息
Department of Obstetrics and Gynecology, Washington Hospital Center, Washington, DC, USA.
出版信息
Am J Obstet Gynecol. 2008 Sep;199(3):278.e1-5. doi: 10.1016/j.ajog.2008.06.066.
OBJECTIVE
The purpose of this study was to test whether vasculopathy in type 1 diabetes mellitus (DM) is associated with fetal growth abnormalities.
STUDY DESIGN
Women with type 1 DM (n = 340) were enrolled in a prospective study of diabetes in pregnancy and classified according to vascular status: NV (no vasculopathy, n = 181), HBR (hypertension or background retinopathy, n = 79), PR (proliferative retinopathy only, n = 16), NEP (nephropathy only, n = 40), and PRN (proliferative retinopathy and nephropathy, n = 24). Association of vascular status with low birthweight (LBW) and small for gestational age (SGA) infants was analyzed.
RESULTS
The odds ratios for delivery of a LBW infant compared to women without vasculopathy after controlling for maternal age, gestational age and race were: HBR 1.0, PR 2.2, NEP 3.7, and PRN 5.5. The odds ratios for delivery of a SGA infant were: HBR 0.7, PR 10.4, NEP 1.9, and PRN 9.9.
CONCLUSION
Diabetic vasculopathy is associated with increased odds for delivery of low-birthweight or SGA infants.
目的
本研究旨在检验1型糖尿病（DM）中的血管病变是否与胎儿生长异常有关。
研究设计
1型糖尿病女性患者（n = 340）被纳入一项妊娠糖尿病前瞻性研究，并根据血管状况进行分类：NV（无血管病变，n = 181）、HBR（高血压或背景性视网膜病变，n = 79）、PR（仅增殖性视网膜病变，n = 16）、NEP（仅肾病，n = 40）和PRN（增殖性视网膜病变和肾病，n = 24）。分析血管状况与低出生体重（LBW）和小于胎龄（SGA）婴儿的相关性。
结果
在控制产妇年龄、孕周和种族后，与无血管病变的女性相比，分娩低出生体重婴儿的比值比为：HBR 1.0、PR 2.2、NEP 3.7和PRN 5.5。分娩小于胎龄婴儿的比值比为：HBR 0.7、PR 10.4、NEP 1.9和PRN 9.9。
结论
糖尿病血管病变与分娩低出生体重或小于胎龄婴儿的几率增加有关。
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