Diejomaoh Michael F, Gupta Madhu, Farhat Rasheda, Jirous Jiri, Al-Jaber Manal, Mohd Asiya T
Department of Obstetrics and Gynecology, Faculty of Medicine, Kuwait University, Kuwait.
Med Princ Pract. 2009;18(3):233-8. doi: 10.1159/000204356. Epub 2009 Apr 6.
To investigate the intrapartum performance of pregnancies complicated by diabetes mellitus (DM).
A pilot study (April-June 2005) of medical records of patients with DM admitted into the labour wards of the Maternity Hospital, Kuwait, was undertaken. Consecutive patients, matched for age and parity with the study group and with no medical complications, admitted for induction of labour during the study period served as the control. The ethnicity, obstetric/medical history and antenatal course of the index pregnancy were extracted. The intrapartum, postpartum and the neonatal outcome were documented. Statistical analysis was performed using chi(2) and alternative Welch t tests.
During the study period, 3,005 patients were delivered at the hospital, and 177 of these (the study population) presented with DM, an incidence of 5.9%. Another 177 patients admitted for induction of labour served as the control. Of the 177 study patients, 86 (48.6%) were Kuwaitis, and the remaining 91 (51.4%) were non-Kuwaitis, of whom 41 were Arabs (23.2%), 34 Indians (19.2%), and 16 Asians (9%). Of the controls, 65 (36.7%) and 112 (63.3%) were Kuwaitis and non-Kuwaitis, respectively. Of the 177 study patients, 128 (72.3%) presented with gestational DM. The significant complications were pregnancy-induced hypertension (13, 7.3%) and premature rupture of membranes (14, 7.9%). The incidence of caesarean section in the study population (58, 32.8%) was significantly higher than that of the controls (35, 19.8%; p = 0.008). Although the mean gestational ages at delivery in both groups were comparable (p = 0.669), the mean birth weight in the study group was significantly higher, 3.315 +/- 0.605 vs. 3.160 +/- 0.594 kg (p = 0.012). The neonatal complications in the diabetic patients were shoulder dystocia (4, 2.3%) and Erb's palsy (12, 1.1%); there were more perinatal deaths (3) in the control group.
The incidence of DM was high, and the rate of caesarean section significant. The maternal and neonatal morbidity were high. A prospective study is recommended for enhanced management guidelines.
探讨妊娠合并糖尿病(DM)的产时情况。
对科威特妇产医院分娩病房收治的糖尿病患者病历进行一项试点研究(2005年4月至6月)。将研究期间因引产入院、年龄和胎次与研究组匹配且无医疗并发症的连续患者作为对照。提取索引妊娠的种族、产科/病史及产前过程。记录产时、产后及新生儿结局。采用卡方检验和替代韦尔奇t检验进行统计分析。
研究期间,该医院共分娩3005例患者,其中177例(研究人群)患有DM,发病率为5.9%。另外177例因引产入院的患者作为对照。177例研究患者中,86例(48.6%)为科威特人,其余91例(51.4%)为非科威特人,其中41例为阿拉伯人(23.2%),34例为印度人(19.2%),16例为亚洲人(9%)。对照组中,科威特人和非科威特人分别为65例(36.7%)和112例(63.3%)。177例研究患者中,128例(72.3%)为妊娠期糖尿病。主要并发症为妊娠高血压(13例,7.3%)和胎膜早破(14例,7.9%)。研究人群的剖宫产率(58例,32.8%)显著高于对照组(35例,19.8%;p = 0.008)。尽管两组的平均分娩孕周相当(p = 0.669),但研究组的平均出生体重显著更高,分别为3.315±0.605 kg和3.160±0.594 kg(p = 0.012)。糖尿病患者的新生儿并发症为肩难产(4例,2.3%)和臂丛神经麻痹(12例,1.1%);对照组的围产儿死亡更多(3例)。
DM发病率高,剖宫产率显著。母婴发病率高。建议进行前瞻性研究以完善管理指南。