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1
Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease.
Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14106-11. doi: 10.1073/pnas.0801146105. Epub 2008 Sep 4.
3
Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration.
Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4957-66. doi: 10.1167/iovs.09-3381. Epub 2009 May 14.
4
Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.
Exp Cell Res. 2010 Apr 15;316(7):1213-24. doi: 10.1016/j.yexcr.2010.01.005. Epub 2010 Jan 11.
5
Omi/HtrA2 Regulates a Mitochondria-Dependent Apoptotic Pathway in a Murine Model of Septic Encephalopathy.
Cell Physiol Biochem. 2018;49(6):2163-2173. doi: 10.1159/000493819. Epub 2018 Oct 4.
6
Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212.
J Biol Chem. 2007 Apr 13;282(15):10981-7. doi: 10.1074/jbc.M700445200. Epub 2007 Feb 20.
7
Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy.
Biochim Biophys Acta. 2014 Jul;1843(7):1295-307. doi: 10.1016/j.bbamcr.2014.03.027. Epub 2014 Apr 5.
8
A novel role for the mitochondrial HTRA2/OMI protease in aging.
Autophagy. 2013 Mar;9(3):420-1. doi: 10.4161/auto.22920. Epub 2012 Dec 14.
10
Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.
J Biol Chem. 2003 Aug 22;278(34):31469-72. doi: 10.1074/jbc.C300240200. Epub 2003 Jun 30.

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1
Heat shock transcription factor-mediated thermal tolerance and cell size plasticity in marine diatoms.
Nat Commun. 2025 Apr 10;16(1):3404. doi: 10.1038/s41467-025-58547-2.
6
Protease-independent control of parthanatos by HtrA2/Omi.
Cell Mol Life Sci. 2023 Aug 18;80(9):258. doi: 10.1007/s00018-023-04904-7.
7
Integrated analysis of the microbiome and transcriptome in stomach adenocarcinoma.
Open Life Sci. 2023 Jul 15;18(1):20220528. doi: 10.1515/biol-2022-0528. eCollection 2023.
8
Mitochondrial Homeostasis and Mast Cells in Experimental Hepatic Ischemia-Reperfusion Injury of Rats.
Turk J Gastroenterol. 2022 Sep;33(9):777-784. doi: 10.5152/tjg.2022.21911.
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Hormonal Regulation of Renal Fibrosis.
Life (Basel). 2022 May 16;12(5):737. doi: 10.3390/life12050737.

本文引用的文献

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Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons.
Nature. 2008 Mar 6;452(7183):98-102. doi: 10.1038/nature06604. Epub 2008 Feb 20.
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Allosteric activation of DegS, a stress sensor PDZ protease.
Cell. 2007 Nov 2;131(3):572-83. doi: 10.1016/j.cell.2007.08.044.
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The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.
Nat Cell Biol. 2007 Nov;9(11):1243-52. doi: 10.1038/ncb1644. Epub 2007 Sep 30.
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Proteome-wide Identification of HtrA2/Omi Substrates.
J Proteome Res. 2007 Mar;6(3):1006-15. doi: 10.1021/pr060510d. Epub 2007 Feb 1.
5
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
Biochem Biophys Res Commun. 2006 Jun 9;344(3):948-54. doi: 10.1016/j.bbrc.2006.04.008. Epub 2006 Apr 19.
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Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.
Hum Mol Genet. 2005 Aug 1;14(15):2099-111. doi: 10.1093/hmg/ddi215. Epub 2005 Jun 16.
9
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.
Mol Cell Biol. 2004 Nov;24(22):9848-62. doi: 10.1128/MCB.24.22.9848-9862.2004.
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A PDZ switch for a cellular stress response.
Cell. 2004 May 14;117(4):417-9. doi: 10.1016/s0092-8674(04)00453-2.

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