Jaiswal Pranita, Singh Pawan Kumar, Prasanna Radha
Centre for Conservation and Utilization of Blue Green Algae (CCUBGA), Division of Microbiology, Indian Agricultural Research Institute (IARI), New Delhi 110012, India.
Can J Microbiol. 2008 Sep;54(9):701-17. doi: 10.1139/w08-034.
Allelopathic interactions involving cyanobacteria are being increasingly explored for the pharmaceutical and environmental significance of the bioactive molecules. Among the toxic compounds produced by cyanobacteria, the biosynthetic pathways, regulatory mechanisms, and genes involved are well understood, in relation to biotoxins, whereas the cytotoxins are less investigated. A range of laboratory methods have been developed to detect and identify biotoxins in water as well as the causal organisms; these methods vary greatly in their degree of sophistication and the information they provide. Direct molecular probes are also available to detect and (or) differentiate toxic and nontoxic species from environmental samples. This review collates the information available on the diverse types of toxic bioactive molecules produced by cyanobacteria and provides pointers for effective exploitation of these biologically and industrially significant prokaryotes.
由于生物活性分子具有药学和环境意义，涉及蓝藻的化感相互作用正越来越多地得到研究。在蓝藻产生的有毒化合物中，与生物毒素相关的生物合成途径、调控机制及相关基因已得到充分了解，而细胞毒素的研究较少。已经开发出一系列实验室方法来检测和鉴定水中的生物毒素以及致病生物；这些方法在复杂程度和所提供的信息方面差异很大。也有直接分子探针可用于从环境样本中检测和（或）区分有毒和无毒物种。本综述整理了有关蓝藻产生的各种有毒生物活性分子的现有信息，并为有效利用这些具有生物学和工业意义的原核生物提供了指导。
