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An in vivo multimodal imaging study using MRI and PET of stem cell transplantation after myocardial infarction in rats.

作者信息

Chapon Catherine, Jackson Johanna S, Aboagye Eric O, Herlihy Amy H, Jones William A, Bhakoo Kishore K

机构信息

MRC Clinical Sciences Centre, Imperial College London, UK.

出版信息

Mol Imaging Biol. 2009 Jan-Feb;11(1):31-8. doi: 10.1007/s11307-008-0174-z. Epub 2008 Sep 5.

DOI:10.1007/s11307-008-0174-z
PMID:18773246
Abstract

PURPOSE: The purpose of the study is to track iron-oxide nanoparticle-labelled adult rat bone marrow-derived stem cells (IO-rBMSCs) by magnetic resonance imaging (MRI) and determine their effect in host cardiac tissue using 2-deoxy-2-[F-18]fluoro-D: -glucose-positron emission tomography (FDG-PET). PROCEDURES: Infarcted rats were randomised to receive (1) live IO-rBMSCs by direct local injection, or (2) dead IO-rBMSCs as controls; (3) sham-operated rats received live IO-rBMSCs. The rats were then imaged from 2 days to 6 weeks post-cell implantation using both MRI at 9.4T and FDG-PET. RESULTS: Implanted IO-rBMSCs were visible in the heart by MRI for the duration of the study. Histological analysis confirmed that the implanted IO-rBMSCs were present for up to 6 weeks post-implantation. At 1 week post-IO-rBMSC transplantation, PET studies demonstrated an increase in FDG uptake in infarcted regions implanted with live IO-rBMSC compared to controls. CONCLUSIONS: Noninvasive multimodality imaging allowed us to visualise IO-rBMSCs and establish their affect on cardiac function in a rat model of myocardial infarction (MI).

摘要

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本文引用的文献

[1]
No evidence of myocardial restoration following transplantation of mononuclear bone marrow cells in coronary bypass grafting surgery patients based upon cardiac SPECT and 18F-PET.

BMC Med Imaging. 2006-7-14

[2]
Non-invasive imaging of atherosclerotic plaque macrophage in a rabbit model with F-18 FDG PET: a histopathological correlation.

BMC Nucl Med. 2006-5-25

[3]
Iron particles for noninvasive monitoring of bone marrow stromal cell engraftment into, and isolation of viable engrafted donor cells from, the heart.

Stem Cells. 2006-8

[4]
Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction.

Nat Med. 2006-4

[5]
Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction.

Circulation. 2005-9-6

[6]
Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction.

Proc Natl Acad Sci U S A. 2005-8-9

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Circulation. 2005-7-12

[8]
Reduction of myocardial scar size after implantation of mesenchymal stem cells in rats: what is the mechanism?

Stem Cells Dev. 2005-6

[9]
Non-invasive analysis of myoblast transplants in rodent cardiac muscle.

Int J Cardiovasc Imaging. 2004-12

[10]
In vivo MRI of embryonic stem cells in a mouse model of myocardial infarction.

Magn Reson Med. 2004-11

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