Alsharif Mariam, Aslan Deniz L, Jessurun Jose, Gulbahce H Evin, Pambuccian Stefan E
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Diagn Cytopathol. 2008 Oct;36(10):734-8. doi: 10.1002/dc.20881.
A 42-year-old man presented with severe abdominal pain, constipation, and hematuria. The patient had a history of seminoma treated by chemotherapy followed by bilateral orchiectomy and retroperitoneal lymph node dissection 16 years earlier. A computed tomography (CT) scan showed a 8.0 x 6.0 x 5.0 cm mass in the retrovesical space, encompassing the left side of his proximal bladder, the prostate, and the rectum. A urine cytologic specimen showed loosely cohesive cell clusters composed of highly atypical large cells and occasional large, single cells with macronucleoli present in a background of mainly lymphocytes and histiocytes was diagnosed as recurrent seminoma. Prostate biopsies showed extensively necrotic seminoma with accompanying granulomatous reaction. The tumor cells were immunoreactive for c-kit (CD117), placental-like alkaline phosphatase (PLAP), D2-40, and OCT4. To our knowledge, this is the second report on urine cytology of metastatic seminoma.
一名42岁男性出现严重腹痛、便秘和血尿。该患者16年前有精原细胞瘤病史，接受过化疗，随后行双侧睾丸切除术和腹膜后淋巴结清扫术。计算机断层扫描（CT）显示膀胱后间隙有一个8.0×6.0×5.0 cm的肿块，包绕近端膀胱左侧、前列腺和直肠。一份尿液细胞学标本显示，在以淋巴细胞和组织细胞为主的背景中，有由高度非典型大细胞组成的松散黏附细胞团以及偶尔出现的带有大核仁的单个大细胞，被诊断为复发性精原细胞瘤。前列腺活检显示广泛坏死的精原细胞瘤伴有肉芽肿反应。肿瘤细胞对c-kit（CD117）、胎盘样碱性磷酸酶（PLAP）、D2-40和OCT4呈免疫反应性。据我们所知，这是关于转移性精原细胞瘤尿液细胞学的第二篇报道。
