发育过程中节点流的流体动力学与左右模式形成

Fluid dynamics of nodal flow and left-right patterning in development.

作者信息

Cartwright Julyan H E, Piro Nicolas, Piro Oreste, Tuval Idan

机构信息

Instituto Andaluz de Ciencias de la Tierra, CSIC-Universidad de Granada, Campus Fuentenueva, Granada, Spain.

出版信息

Dev Dyn. 2008 Dec;237(12):3477-90. doi: 10.1002/dvdy.21672.

DOI:10.1002/dvdy.21672

PMID:18773487

Abstract

The manner in which the nodal flow determines the breaking of left-right symmetry during development is a beautiful example of the application of fluid dynamics to developmental biology. Detailed understanding of this crucial developmental process has greatly advanced by the transfer of ideas between these two disciplines. In this article, we review our and others' work on applying fluid dynamics and dynamical systems to the problem of left-right symmetry breaking in vertebrates.

摘要

在发育过程中，节点流决定左右对称性打破的方式，是流体动力学在发育生物学中应用的一个绝佳例子。通过这两个学科之间思想的转移，对这一关键发育过程的详细理解有了很大进展。在本文中，我们回顾了我们自己以及其他人在将流体动力学和动力系统应用于脊椎动物左右对称性打破问题上所做的工作。