Gandon Sylvain, Day Troy
CEFE-UMR 5175, 1919 Route de Mende, F-34293 Montpellier Cedex 5, France.
Vaccine. 2008 Jul 18;26 Suppl 3:C4-7. doi: 10.1016/j.vaccine.2008.02.007.
We present a brief review of some of the empirical evidence of parasite evolution in response to vaccination. The available data shows that very different pathogen strategies can be selectively favored as a result of vaccination. However, this data often lacks a qualitative and/or quantitative assessment of the benefits and the costs associated with these alternative strategies. Without this type of information to calibrate theoretical models it will be difficult to predict the potential risks associated with vaccine-induced evolution. Our purpose here is therefore to stimulate future research into quantifying these effects.
我们简要回顾了一些关于寄生虫针对疫苗接种而发生进化的实证证据。现有数据表明,由于疫苗接种,截然不同的病原体策略可能会被选择性地青睐。然而,这些数据往往缺乏对与这些替代策略相关的益处和成本的定性和/或定量评估。如果没有这类信息来校准理论模型,就很难预测与疫苗诱导的进化相关的潜在风险。因此,我们在此的目的是推动未来对量化这些影响的研究。