Qi Wen-Juan, Fang Qiang
Department of Immunology, Bengbu Medical College, Bengbu 233030, China.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2011 Jun;23(3):340-4.
One of the effective prevention and treatment strategies to parasitosis is to develop safe and effective vaccines. The DNA vaccine is a new kind of vaccine developed in last 10 years. In recent years, many advances in DNA vaccines against parasitosis have been made. This article reviews the advances in the mechanism, construction, optimization, adjuvants and delivery ways of DNA vaccines and the advances in the study of DNA vaccines against some parasitosis including malaria, schistosomiasis, cysticercosis and toxoplasmosis in recent years.
寄生虫病有效的防治策略之一是研发安全有效的疫苗。DNA疫苗是近十年发展起来的新型疫苗。近年来,抗寄生虫病DNA疫苗研究取得了许多进展。本文综述了DNA疫苗的作用机制、构建、优化、佐剂及递送方式等方面的研究进展,以及近年来抗疟原虫、血吸虫、囊尾蚴和弓形虫等寄生虫病DNA疫苗的研究进展。