Osada H
Department of Environmental Physiology, Shinshu University, Japan.
Acta Physiol Scand. 1991 Jun;142(2):261-6. doi: 10.1111/j.1748-1716.1991.tb09155.x.
One hundred and five male (Hartley) guinea-pigs weighing 350-380 g and 30 splenectomized guinea-pigs were exposed to simulated hypobaric hypoxia of 50.6 kPa (equal to an altitude of 5486 m) for 14 days. The partial pressure of oxygen was set at half that at sea level. The white blood cell count increased significantly on day 3 of the simulated high altitude experiment but returned to normal on day 7, whereas the red blood cell count increased continuously. To study the effect of high altitude exposure on platelets, the platelet count in the splenectomized group was compared to that in a non-splenectomized group. Investigation of the resistance of red blood cell membranes to osmotic pressure under hypobaric conditions revealed a shift of the onset of haemolysis in the hyperosmotic direction. These findings may help to increase our understanding of the biochemical mechanisms of adaptation to hypobaric hypoxia.
105只体重350 - 380克的雄性（哈特利）豚鼠和30只脾切除的豚鼠被暴露于50.6千帕的模拟低压低氧环境（相当于海拔5486米）中14天。氧气分压设定为海平面时的一半。在模拟高原实验的第3天白细胞计数显著增加，但在第7天恢复正常，而红细胞计数持续增加。为了研究高原暴露对血小板的影响，将脾切除组的血小板计数与非脾切除组进行比较。在低压条件下对红细胞膜渗透压抗性的研究显示溶血起始向高渗方向偏移。这些发现可能有助于增进我们对适应低压低氧生化机制的理解。
