Quatrini U, Benigno A, Orlando F
Rev Can Biol. 1981 Jun;40(2):159-66.
Albino rats of the Wistar family were raised from the time of birth in a simulated altitude of about 6000 meters (barometric pressure 370 mm Hg) for a period of about 50 days. Part of these were killed after losing consciousness upon exposure to acute hypoxia. The other groups were killed without being first subjected to acute hypoxia. Control groups of the some stock were raised for a corresponding period of time in a normal atmosphere at sea level and killed like the preceding. We were not able to demonstrate significant variations in tolerance to acute hypoxia in the various groups studied. Instead the animals raised in a simulated altitude displayed an increase in the 2,3-DPG content in the red blood cells, Hb concentration and the number of erythrocytes for mm3 of blood. The animals raised in a simulated altitude also displayed a displacement of the acid-base balance of blood towards the acid side. This was even more accentuated in the group subjected to acute hypoxia. Finally, it was observed, via the weight curve, that the animals raised in a simulated altitude presented a slower body growth in comparison to the control group.
将Wistar品系的白化大鼠从出生起就在模拟海拔约6000米（气压370毫米汞柱）的环境中饲养约50天。其中一部分在急性缺氧后失去意识时被处死。其他组则未先经历急性缺氧就被处死。选取相同品系的对照组在海平面正常大气环境中饲养相应时间，并按上述方式处死。在我们所研究的各个组中，未能证明对急性缺氧的耐受性存在显著差异。相反，在模拟海拔环境中饲养的动物，其红细胞中的2,3 -二磷酸甘油酸（2,3 - DPG）含量、血红蛋白（Hb）浓度以及每立方毫米血液中的红细胞数量均有所增加。在模拟海拔环境中饲养的动物，其血液酸碱平衡也向酸性方向偏移，在经历急性缺氧的组中这种情况更为明显。最后，通过体重曲线观察到，与对照组相比，在模拟海拔环境中饲养的动物身体生长较慢。
