Ohshima K, Matsuo N, Yokoe S, Yoshino T, Akagi T
Department of Ophthalmology, Okayama University Medical School, Japan.
Nippon Ganka Gakkai Zasshi. 1991 Apr;95(4):386-92.
A 64 year-old female complained of left upper lid swelling. Painless mass lesions were found in her bilateral lacrimal gland areas. She also complained of a dry sensation in both eyes and her mouth. The rose bengal test, Schirmer's test and fluorescein dye test were positive. Lip biopsy revealed chronic sialoadenitis and rheumatoid factor titer was elevated. Anti-nuclear and anti-RNP antibodies were positive. Anti-SS-A and anti-SS-B antibodies were both negative. Left pre-and post auricular, cervical and inguinal lymph nodes were palpable. Excisional biopsies of bilateral orbital lesions and an inguinal lymph node revealed the presence of reactive lymphoid hyperplasia in the right orbit, and B cell type, diffuse, large cell lymphoma, in the left orbit and inguinal lymph node. Intensive chemotherapy resulted in complete remission. Lacrimal gland lymphoma must be considered when examining cases of Sjogren's syndrome.
一名64岁女性主诉左上眼睑肿胀。在其双侧泪腺区域发现无痛性肿块病变。她还主诉双眼及口腔有干燥感。孟加拉玫瑰红试验、泪液分泌试验和荧光素染色试验均为阳性。唇活检显示慢性涎腺炎，类风湿因子滴度升高。抗核抗体和抗核糖核蛋白抗体呈阳性。抗SS - A和抗SS - B抗体均为阴性。左耳前、耳后、颈部和腹股沟淋巴结可触及。双侧眼眶病变及腹股沟淋巴结切除活检显示，右侧眼眶存在反应性淋巴样增生，左侧眼眶及腹股沟淋巴结为B细胞型弥漫性大细胞淋巴瘤。强化化疗导致完全缓解。在检查干燥综合征病例时，必须考虑泪腺淋巴瘤。
