Ooms Kristopher J, Cannella Marco, Vega Alexander J, Marcolongo Michele, Polenova Tatyana
Department of Chemistry and Biochemistry, University of Delaware, 036 Brown Laboratories, Newark, DE 19716, USA.
J Magn Reson. 2008 Nov;195(1):112-5. doi: 10.1016/j.jmr.2008.07.024. Epub 2008 Aug 7.
A method for acquiring triple quantum filtered (TQF) (23)Na NMR images is proposed that takes advantage of the differences in transverse relaxation rates of sodium to achieve positive intensity, PI, NMR signal. This PITQF imaging sequence has been used to obtain spatially resolved one-dimensional images as a function of the TQF creation time, tau, for two human spinal disc samples. From the images the different parts of the tissue, nucleus pulposus and annulus fibrosus, can be clearly distinguished based on their signal intensity and creation time profiles. These results establish the feasibility of (23)Na TQF imaging and demonstrate that this method should be applicable for studying human disc tissues as well as spinal disc degeneration.
提出了一种获取三重量子滤波(TQF)(23)Na NMR图像的方法,该方法利用钠横向弛豫率的差异来实现正强度的NMR信号。这种PI TQF成像序列已用于获取两个人类椎间盘样本作为TQF创建时间tau的函数的空间分辨一维图像。从图像中可以根据组织的不同部分,即髓核和纤维环的信号强度和创建时间轮廓清楚地区分它们。这些结果证实了(23)Na TQF成像的可行性,并表明该方法应适用于研究人类椎间盘组织以及椎间盘退变。