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神经生长因子和促卵泡激素对未成熟小鼠卵巢中肾母细胞瘤基因表达的调控

Regulation of Wilms' tumor gene expression by nerve growth factor and follicle-stimulating hormone in the immature mouse ovary.

作者信息

Roh Jaesook, Bae Jeehyeon, Lee Kangseok, Mayo Kelly, Shea Lonnie, Woodruff Teresa K

机构信息

Department of Obstetrics & Gynecology, Hanyang Medical University, Seoul, Korea.

出版信息

Fertil Steril. 2009 Apr;91(4 Suppl):1451-4. doi: 10.1016/j.fertnstert.2008.07.012. Epub 2008 Sep 6.

DOI:10.1016/j.fertnstert.2008.07.012
PMID:18774569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2749456/
Abstract

This study investigated the regulation of Wilms' tumor gene (WT1) in the ovary by nerve growth factor and FSH to better understand signals that initiate early follicular growth. Nerve growth factor showed a direct stimulatory effect on endogenous expression of WT1, whereas FSH attenuated basal and nerve growth factor-stimulated WT1 protein expression, which most likely depended on FSH responsiveness according to the follicle growth stage.

摘要

本研究调查了神经生长因子和促卵泡激素对卵巢中威尔姆斯瘤基因（WT1）的调控，以更好地了解启动早期卵泡生长的信号。神经生长因子对WT1的内源性表达具有直接刺激作用，而促卵泡激素则减弱了基础状态和神经生长因子刺激下的WT1蛋白表达，这很可能取决于卵泡生长阶段的促卵泡激素反应性。

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本文引用的文献

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WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells.WT1和DAX-1调节性腺细胞中SF-1介导的人类P450芳香化酶基因表达。
Mol Cell Endocrinol. 2003 Oct 31;208(1-2):61-75. doi: 10.1016/s0303-7207(03)00198-9.
2
Role of Wilms tumor 1 (WT1) in the transcriptional regulation of the Mullerian-inhibiting substance promoter.肾母细胞瘤1（WT1）在苗勒管抑制物质启动子转录调控中的作用
Biol Reprod. 2003 Dec;69(6):1808-14. doi: 10.1095/biolreprod.103.015826. Epub 2003 Jul 9.
3
WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells.WT1和DAX-1抑制人子宫内膜及子宫内膜异位症基质细胞中芳香化酶P450的表达。
J Clin Endocrinol Metab. 2002 Sep;87(9):4369-77. doi: 10.1210/jc.2002-020522.
4
Nerve growth factor induces the expression of functional FSH receptors in newly formed follicles of the rat ovary.神经生长因子诱导大鼠卵巢新形成卵泡中功能性促卵泡激素受体的表达。
Endocrinology. 2002 Apr;143(4):1485-94. doi: 10.1210/endo.143.4.8711.
5
Nerve growth factor is required for early follicular development in the mammalian ovary.神经生长因子是哺乳动物卵巢早期卵泡发育所必需的。
Endocrinology. 2001 May;142(5):2078-86. doi: 10.1210/endo.142.5.8126.
6
The Wilms' tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cells.威尔姆斯瘤基因产物WT1介导神经生长因子对PC12细胞中大鼠表皮生长因子受体的下调作用。
J Biol Chem. 2001 Feb 16;276(7):5068-73. doi: 10.1074/jbc.M008776200. Epub 2000 Nov 8.
7
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J Biol Chem. 2000 Jun 9;275(23):17566-70. doi: 10.1074/jbc.C000140200.
8
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Mol Endocrinol. 1995 Oct;9(10):1356-66. doi: 10.1210/mend.9.10.8544844.