基于亚砜前体荧光团的荧光信号：在爆炸物三过氧化三丙酮视觉检测中的应用

Fluorescent signaling based on sulfoxide profluorophores: application to the visual detection of the explosive TATP.

作者信息

Malashikhin Sergey, Finney Nathaniel S

机构信息

Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

出版信息

J Am Chem Soc. 2008 Oct 1;130(39):12846-7. doi: 10.1021/ja802989v. Epub 2008 Sep 6.

DOI:10.1021/ja802989v

PMID:18774810

Abstract

The first visual fluorescence-based assay for the peroxide explosive triacetone triperoxide (TATP) is described. The assay is based on a conceptually new fluorescence signaling mechanism, in which nonemissive pyrenyl sulfoxide profluorophores are oxidized to visibly emissive pyrenyl sulfones. Although not without limitations, these first-generation fluorescent probes can provide a visual response to ca. 100 nmol of TATP. In addition, the success of this assay suggests the potential for broader application of aryl sulfoxides in fluorescent chemosensing.

摘要

本文描述了首个基于视觉荧光的过氧化物炸药三丙酮三过氧化物（TATP）检测方法。该检测方法基于一种概念全新的荧光信号传导机制，即无发射性的芘基亚砜前体荧光团被氧化为具有可见发射性的芘基砜。尽管存在局限性，但这些第一代荧光探针能够对约100 nmol的TATP产生视觉响应。此外，该检测方法的成功表明芳基亚砜在荧光化学传感方面具有更广泛应用的潜力。